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  • Mighty Mouse V2


    Comparison of body and muscle size between normal (left) and double mutant mice lacking myostatin and overproducing follistatin (right).

    28-Aug-2007

    The Johns Hopkins scientist who first showed that the absence of the protein myostatin leads to oversized muscles in mice and men has now found a second protein, follistatin, whose overproduction in mice lacking myostatin doubles the muscle-building effect.

    Results of Se-Jin Lee’s new study, appearing on August 29 in the online, open-access journal PLoS ONE, show that while mice that lack the gene that makes myostatin have roughly twice the amount of body muscle as normal, mice without myostatin that also overproduce follistatin have about four times as much muscle as normal mice.

    Lee, M.D., Ph.D., a professor of molecular biology and genetics, says that this added muscle increase could significantly boost research efforts to “beef up” livestock or promote muscle growth in patients with muscular dystrophy and other wasting diseases.

    Specifically, Lee first discovered that follistatin was capable of blocking myostatin activity in muscle cells grown under lab conditions. When he gave it to normal mice, the rodents bulked up, just as would happen if the myostatin gene in these animals was turned off. He then genetically engineered a mouse that both lacked myostatin and made extra follistatin. If follistatin was increasing muscle growth solely by blocking myostatin, then Lee surmised that follistatin would have no added effect in the absence of myostatin.

    “To my surprise and delight, there was an additive effect,” said Lee, who notes these muscular mice averaged a 117 percent increase in muscle fiber size and a 73 percent increase in total muscle fibers compared to normal mice.

    “These findings show that the capacity for increasing muscle growth by targeting these pathways is much more extensive than we have appreciated,” adds Lee. “Now we’ll search for other players that cooperate with myostatin, so we can tap the full potential for enhancing muscle growth for clinical applications.”

    Lee adds that this issue is of particular significance, as most agents targeting this pathway, including one drug being currently tested in a muscular dystrophy clinical trial, have been designed to block only myostatin and not other related proteins.

  • #2
    Quadrupling Muscle Mass in Mice by Targeting TGF-ß Signaling Pathways

    .PDF
    Attached Files

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    • #3
      That's one shredded mouse

      Comment


      • #4
        Then there's the Jacked Cow...



        and these bad ass whippets i found too.







        myostatin blockers are kinda freaky. :/ There's one human born in Germany that has insufficient myostatin, already at 5 y/o he's twice as strong as kids his age. but it's unnatural ... i beleive our bodys are made a certain way for a reason, and you take away part of it, it won't be for the better. however myostatin blockers could have medicinal purposes
        Last edited by RenegadeRows; 09-07-2007, 06:20 AM.

        Comment


        • #5
          Imagine blocking the myostatin in a pitbull ...

          Comment


          • #6
            Originally posted by RenegadeRows

            Comment


            • #7
              nice. :looks to get it made:
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              • #8
                Originally posted by Controlled Labs
                nice. :looks to get it made:
                That would be pretty sweet.
                They have the fake knockoffs...
                http://www.bodybuilding.com/store/myostat.html

                Comment


                • #9
                  Originally posted by RenegadeRows
                  That would be pretty sweet.
                  They have the fake knockoffs...
                  http://www.bodybuilding.com/store/myostat.html
                  :looks for real stuff:
                  REDuction SHOTS are Now Here!

                  Out Now:
                  Orange OxiMega (Fish Oil & Greens)
                  Purple Psyko
                  Gold Feast
                  Blue Gene
                  Blue Growth
                  REDuction AM/PM Shots
                  REDuction AM/PM (and PM solo)
                  Orange TRIad
                  White Flood (5 Flavors)
                  Black Hole
                  Green MAGnitude (apple or lemonade)
                  Green Bulge
                  White Blood 2
                  Purple Wraath (grape or lemonade)
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                  Comment


                  • #10
                    Originally posted by Controlled Labs
                    :looks for real stuff:

                    Comment


                    • #11
                      Nice find PT


                      Originally posted by Controlled Labs
                      :looks for real stuff:
                      for only 5200 per mg you can get some online http://www.peprotech.com/product.asp...ase+Catalog%29
                      Last edited by Dr.Dave1; 09-07-2007, 08:41 AM.
                      Disclaimer: While I have an M.D. the views I express are not to be taken as medical advice under any circumstances. Please check with your own doctor if you want medical advice as he/she has access to your info and can provide the most accurate advice.


                      www.pubmed.gov . . . gotta love it

                      Comment


                      • #12
                        I'm pretty sure that there are more than likely significant negative consequences of blocking myostation..

                        I believe im going to get taught all about the stuff in my exercise physiology class this fall.. i'll get back if i dooo

                        Comment


                        • #13


                          Wow look at those results. Only took 16 weeks and in 10 weeks he grew a tattoo

                          Comment


                          • #14
                            Yay Myostatain!
                            Supplements.net Board Rep

                            Quality, Supplements at Great Prices.

                            Comment


                            • #15
                              Originally posted by Dr.Dave1
                              Nice find PT



                              for only 5200 per mg you can get some online http://www.peprotech.com/product.asp...ase+Catalog%29
                              money is no object
                              REDuction SHOTS are Now Here!

                              Out Now:
                              Orange OxiMega (Fish Oil & Greens)
                              Purple Psyko
                              Gold Feast
                              Blue Gene
                              Blue Growth
                              REDuction AM/PM Shots
                              REDuction AM/PM (and PM solo)
                              Orange TRIad
                              White Flood (5 Flavors)
                              Black Hole
                              Green MAGnitude (apple or lemonade)
                              Green Bulge
                              White Blood 2
                              Purple Wraath (grape or lemonade)
                              Blue Up
                              Blue Up (Stim-Free)
                              GlycerGrow (Elements line)
                              CLAmore (Elements Line)

                              Toll Free: (800) 692-4558
                              Tank "@" ControlledLabs.com

                              Comment

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