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Thread: Dinoiii's Bringin' Sexy Back: Yellow nEuphoria (B)log!!!

  1. #41
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    Default Day 13



    WEEK 2: Scientific Analysis – Double-Blind, Placebo-Controlled Trial
    Day 13 (Dec 23, 2006): 2 capsules Yellow nEuphoria -OR- placebo???

    Supplement Time: taken @ 7:30am; workout @ 8:00am (unfortunately my gym opens at 8:00am on Saturday, so I had to push it back today as last week)

    Dose Used: * Today’s dose included 2 caps of yellow pill, envelope was marked as Saturday…we will NOT find out until tomorrow which days apply to actual product ingestion and which days apply to placebo!


    Supplement/Placebo Effects:

    Subjective – Reminder: The subjective components have been extracted from the Controlled Labs Yellow Neuphoria FAQ page. All parameters being “claimed” will be assessed on subjective rating scale.

    (1) Depressed Appetite: (-) (Nothing really at all to report here today. Appetite was intact; no changes in overall GI emetic/satiety state – kind of describe it as indifferent!).
    (2) Alertness: * (Pretty solid workout and I was readily able to go, but without shoulder deterrent – i.e. – it felt pretty good today, harder to assess this in all honesty versus yesterday. No significant improvements, but based on thought – likely NOT the supplement – dinoiii crosses fingers in hopes he is right)
    (3) Decreased Stress Effects: (-) (Nothing here to report again. Going to go on assumption and say this was NOT the YN).
    (4) Decreased Fatigue: ** (No change from day prior…NEED MORE STUDY!)
    (5) Mental Focus: ** (No change from yesterday!!!)
    (6) Mood: ** (No significant changes from yesterday – hope to have an answer with Sunday’s unveiling!)
    (7) Libido: (-) Ummmm, thus far … NOT tested.
    (8) Endurance & Stamina: ** (Nothing to report outside of what has already been said last week on this one; i.e. – no change).

    Dinoiii's Rating Scale KEY:
    * Insignificant Effect
    ** Slight Effect, Still Insignificant
    *** Average Effect
    **** Statistically Significant Effect
    ***** Dinoiii's Praise (statistical significance doesn't describe this!)

    Today’s Experience:
    * Dinoiii’s Reiteration: I will write down my experience with the pill selected today and its effects or lack thereof at the half-hour marks (highlighted) and will write down a very subjective interpretation of effects highlighted. These are direct notes I have jotted down signifying my personal experience in my own log. Note: when I opened the packet this morning and downed the pills, I wrote “Friday” across the front of the envelope and placed it in an alternative bag (different from “randomized” bag). I will NOT uncover what pill this was until Sunday’s log – stay tuned for that one…


    Times = POST-INGESTION:
    15 minutes: No effect noted thus far.

    30 minutes: No effect noted.

    60 minutes: Focus was average today as noted above and generalized mood was likely that matched with baseline. Now, if this is solely placebo – I have created quite a strong placebo effect for myself. Again, I could be the deterrent. And the nocebo could be rearing its ugly head – but again time will tell. [NEED MORE STUDY!]

    90 minutes: Overall Ancillary Workout rating: 5-6 out of 10. This is not to worry in regards to the supplement (should it have been chosen), I always rate my workouts low…when I say I had a 7-8…you know it was the real deal (and this was close…weights + reps in order and solid today; fatigue of the muscles, et al indifferent). I guess I am saying that overall it was a decent workout. I have already taken my post-workout beverage (self-concoction as described in pre-log sign up).

    120 minutes: No true effects believed to be seen. Bystanders concur.

    150 minutes: No effects believed to have been seen.

    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

    Objective –

    (1) Blood Pressure
    * measured via automated cuff; last calibrated on Dec 10, 2006

    Baseline: 110-120/60-80
    Before Supplement (this AM): 112/68
    After Supplement (15 minutes post-ingestion; pre-workout): 114/70
    After Supplement (30 minutes post-ingestion; pre-workout): 114/66
    After Supplement (90 minutes post-ingestion; post-workout): 120/72
    After Supplement (120 minutes post-ingestion; post-workout): 118/70

    (2) Pertinent Labs Drawn yesterday:

    - Complete Metabolic Panel (focus on liver function profile and glucose levels for rationale suggested earlier in log)
    - CPK – without this, as I have said SO many times in the past…for a hard-working (namely in the myofibril abused bodies we have from the gym), “liver” function tests would be WORTHLESS without it, unless you spend 24-48 hours away from the gym prior to the blood draw…this was not the case!
    - Endocrine: Test (Free, Total, SHBG), Estradiol, LH, FSH

    Rationale: evaluation for side effect potential (stay tuned). NEXT WEEK we’ll see the results as they come in after the holiday.

    (3) Electromyography (EMG) to assess muscle contractile effects later in trial (stay tuned). – NEXT WEEK when out of placebo-control.

    ------------------------------------------

    Today’s Workout Notes:

    Ancillary Notes: While I cannot unfortunately list direct sets/reps info (due to the training modality’s inclusion in a forthcoming book), I can offer up bigger lifts and any effect seen as well as some elctromyographic (EMG) reports throughout.

    Major Lifts ONLY

    Overhead Barbell Press: Max Lift w/ reps today: 225 pounds x 12/4/2 reps (Rest-Pause) – not max lifts. [vs. last week: (-)/-2/-2; so overall a 4 rep DECREASE – YUCK! Not what I wanted to have happen]

    Dinoiii’s note: now, there were some other positive shoulder movements, but I am not tracking them for this log - but for comparative analysis, I would say they were minimal significance overall anyway.

    Farmer's Carries: Max Lift w/ reps today: 110 pounds each arm for a total of 675 steps- NOT max lift. I am hoping the numbers make sense...if not, let me know below. [vs. last week – same weight; step increase of +49, but was highly focused to beat last week and some of the strength lifts, while great for forearm development, can not offer us much ability to distinguish how much is solely inner fortitude due to the pure nature of the lifts.]

    Barbell Shrugs: Max Lift w/ reps today: 435 pounds x 12/5/1 reps (Rest-Pause). [vs. last week – same weight; reps: +2/+1/-1…no statistically significant difference.]

    --------------------------------------------

    Today’s Diet Notes:

    Again, same issue with the diet notes, I cannot fully disclose meal for meal what I am trying out due to a future book. However, some important things will be monitored due to the types of sides suggested as usual potential for various supps – namely appetite seemed to take a dip today and I was overall "full" for the better part of the day. I am taking 2 yellow pills (placebo vs. YN) – effects on appetite were not noted today at all.

    Caloric Intake: 4200 calories divided over 8 meals

    Macronutrient Notes: I cycle macros, today was again higher-carb. With 1 meal to go as of this writing, it again is difficult to discern supplement effects versus increased caloric intake / carb tally. At the end of the log, we will make some inferences as to how I might discern the two.

    ---------------------------------------

    Tomorrow's Preview:

    (1) NO Independent Supplement Review – this will be moved to Monday because of the holiday – my gym is closed Christmas day, which may have some bearing because I do NOT like to work out this many days in a row without a day off. We’ll see.

    (2) Randomization Results / Statistical Analysis, Week 2 Summary, Some notes to discuss the upcoming week.

    (3) Another logged chest day (final day of placebo vs. YN).

    DO NOT MISS THIS ONE!!!

    ---------------------------------------


  2. #42
    Join Date
    Dec 2006
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    Default Day 14



    WEEK 2: Scientific Analysis – Double-Blind, Placebo-Controlled Trial
    Day 14 (Dec 24, 2006): 2 capsules Yellow nEuphoria -OR- placebo???


    Supplement Time: taken @ 7:30am; workout @ 8:00am
    * Please Note: due to the Christmas holiday, this time is obviously affected. My gym apparently had forgot to check with me to gel their AM availabilities with my Yellow nEuphoria trial here for Monday morning. I have pushed the chest workout back into Sunday and thereby not allowing for a “missed” workout (could play out as an uncontrolled for factor).

    Dose Used: * Today’s dose included 2 caps of yellow pill, envelope was marked as “Sunday”…we will NOT find out until after today’s effects which days apply to actual product ingestion and which days apply to placebo! Complete analysis to follow this (b)log entry.


    Supplement/Placebo Effects:

    Subjective – Reminder: The subjective components have been extracted from the Controlled Labs Yellow Neuphoria FAQ page. All parameters being “claimed” will be assessed on subjective rating scale.

    (1) Depressed Appetite: **** (Similar feeling to last week; decent satiety all day, inclusive of times falling outside of the immediate workout timeframe.).
    (2) Alertness: *** (Average here, no deterrent from the effect…again keep in mind that I do NOT dub “alert” the same as I would “focused”)
    (3) Decreased Stress Effects: *** (Again, my lifestyle precludes my ability to discern what effect may or may not be attributable to the potential of the yellow pill ingested today, but this still seemed to be something affected by the pill – namely around the workout…whether a good thing or not would NEED MORE STUDY!)
    (4) Decreased Fatigue: ** (Relaxed similar to , no more profound, however! Structured workouts continue to play factor in assessing this adequately – Still toying with an idea for week 4 though…NEED MORE STUDY!)
    (5) Mental Focus: *** (Nothing out of the ordinary to report today, therefore I assign this an average score.)
    (6) Mood: ***** (Highest score on a dinoiii-scale, overall phenom! Still cannot say enough here though again, must ask if this is attributable to receiving a supplement packet today or my own placebo???)
    (7) Libido: (-) Ummmm, thus far … NOT tested. You gotta wait still – for those that have been continually checking back for this one, allow for next week to hit to start getting at this (oh no!!! – BUT – oh yes!!! This is a dinoiii log guys…do NOT expect “ordinary”)
    (8) Endurance & Stamina: ** (Nothing to report outside of what has already been said last week on this one).

    Dinoiii's Rating Scale KEY:
    * Insignificant Effect
    ** Slight Effect, Still Insignificant
    *** Average Effect
    **** Statistically Significant Effect
    ***** Dinoiii's Praise (statistical significance doesn't describe this!)

    Today’s Experience:
    * Dinoiii’s Reiteration: I will write down my experience with the pill selected today and its effects or lack thereof at the half-hour marks (highlighted) and will write down a very subjective interpretation of effects highlighted. These are direct notes I have jotted down signifying my personal experience in my own log. Note: when I opened the packet this morning and downed the pills, I wrote “Sunday” across the front of the envelope and placed it in an alternative bag (different from “randomized” bag). I will NOT uncover what pill this was until Sunday’s log – stay tuned for that one…


    Times = POST-INGESTION:
    15 minutes: No effect noted thus far.

    *** 19.75 minutes: I would suggest this to be the time I cite as onset today of what I was describing with last week’s trials (assuming I got the Yellow nEuphoria at this point). Again, NOT a jittery feeling and the crisp silent buzz I was describing is back (apparently a bit shorter-lived though  more later). Is this my own placebo creation? Time will tell…

    30 minutes: Continued effect present…Today was back (will express below how my lifts go). Getting ready to begin workout.

    60 minutes: I believe the effect to have already effectively waned today. I will cite this as time of cessation today. Now, if this is solely placebo – I have created quite a strong placebo effect for myself. Again, I could be the deterrent. [NEED MORE STUDY!]

    90 minutes: Overall Chest Workout workout rating: 5-6 out of 10. This is not to worry in regards to the supplement, I always rate my workouts low…when I say I had a 7-8…you know it was the real deal (and this was close…weights were stable in reps today, but more secondary to shoulder injury I alerted you to during last week’s log…not fatigue of the muscles, et al. I even attempted rest-pause and strip sets without a hitch to assess this and because it was Christmas eve and the crowd in the gym was different than norm). I guess I am saying that overall it was an average workout. I have already taken my post-workout beverage (self-concoction as described in pre-log sign up).

    120 minutes: Effects of positive mood, et al have long-since waned. Effect agreed upon by bystanders today.

    150 minutes: Effects not present.

    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

    Objective –

    (1) Blood Pressure
    * measured via automated cuff; last calibrated on Dec 10, 2006

    Baseline: 110-120/60-80
    Before Supplement (this AM): 116/66
    After Supplement (15 minutes post-ingestion; pre-workout): 114/72
    After Supplement (30 minutes post-ingestion; pre-workout): 118/70
    After Supplement (90 minutes post-ingestion; post-workout): 126/78
    After Supplement (120 minutes post-ingestion; post-workout): 122/66

    (2) Labs from Friday results reported after the holiday // rationale: evaluation for side effect potential (stay tuned).

    (3) Electromyography (EMG) to assess muscle contractile effects later in trial (stay tuned). – NEXT WEEK when out of placebo-control.

    ------------------------------------------

    Today’s Workout Notes:

    Chest Notes: While I cannot unfortunately list direct sets/reps info (due to the training modality’s inclusion in a forthcoming book), I can offer up bigger lifts and any effect seen as well as some elctromyographic (EMG) reports throughout.

    Major Lifts ONLY

    Flat Chest Press: Max Lift w/ reps today: 315 pounds x 7 reps (since shoulder injury in April, this has been my max however – prior to that time, I had gone up to 450 x 3 clean reps as a max lift) – there was NO +/- in weight today vs. last workout – has remained stable due to my shoulder and the pain I am already battling with it. Unfortunately, my shoulder is a limiting factor here as mentioned the previous two weeks and it should NOT be construed as either placebo NOR supplement effects – one that I am much aware of … As I attempt certain lifts (like pressing moves, incline + flat only), I cannot progress past a certain point (in pounds – it becomes too difficult mentally to overcome the pain and I call it a day – 315 has been that stagnant position for some time). The pain becomes unbearable at that time and I am already lifting through it past about 250 pounds (65 pounds of essential guts and fight!).

    Incline Dumbbell Chest Press: Max Lift w/ reps today: 110 pounds x 9 clean reps. [This is stable vs. last week] Please Note that I again was limited by pain on this movement about the same as last week and unable to assess whether this is the supplement or placebo, I am not sure it could really be attributed to what was in the pill bottle either way, so I am placing this on the confounding variable list.

    --------------------------------------------

    Today’s Diet Notes:

    Again, same issue with the diet notes, I cannot fully disclose meal for meal what I am trying out due to a future book. However, some important things will be monitored due to the types of sides suggested as usual potential for various supps. If I had to wager, I would say it was the supplement versus the sugar pill because it is clear some effect was seen.

    Caloric Intake was set: 3850 calories divided over 8 meals

    Macronutrient Notes: I cycle macros, today was lowER-carb return…as noted earlier in my log, I don’t tend to get carb cravings as I am VERY self-disciplined; however, could have attributed general full feeling all day to some aid from supplement…usually I can see an episode of ravaging hunger sneak in for at least a meal or two … nothing today (with 1 meal to go as of this writing).

    --------------------------------------------

    What do you think?

    (1) Is dinoiii a victim of placebo/nocebo?
    (2) Is there an actual effect that we can attribute to Yellow nEuphoria should this be what I ingested today?
    (3) How did each day stack up to the pill ingested?

    We’ll see in a minute. On to the unveiling…



  3. #43
    Join Date
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    Default Week 2 Summaries

    First, the unveiling of what was contained in each envelope:

    Monday: Yellow nEuphoria
    Tuesday: Placebo
    Wednesday: Day Off
    Thursday: Yellow nEuphoria
    Friday: Placebo
    Saturday: Placebo
    Sunday: Yellow nEuphoria

    The good news is that the effect was rather predictable on most occasion - Thursday being the most challenging to differentiate as the effect was subtle if you recall from the day-to-day accounts. Some confounding factors that likely contributed to this were the fact that I was really concentrating on not having a repeat terrible leg day as I did in week 1 (recall my "deer in the headlight" effect while on the hack squat machine - verified by bystanders).



    For our comparative analysis of my experience on a star basis of the Yellow nEuphoria vs. Placebo based on claims in the Controlled labs ad campaign look as follows in a table I constructed accounting for averages of the 3 days of each item:



    Now, I will cut and paste the rating scale I have used alongside this trial for your ease:

    Dinoiii's Rating Scale KEY:
    * Insignificant Effect
    ** Slight Effect, Still Insignificant
    *** Average Effect
    **** Statistically Significant Effect
    ***** Dinoiii's Praise (statistical significance doesn't describe this!)


    And for your corneal pleasure....look into the yellow mess below prior to even thinking about asking me to assign statistical significance to these values seen in the table.



    It cannot be done effectively without me "fudging" the numbers due to a small "N" - namely n=1 in this trial, too small a POWER effect to assign significance, however - it does affirm that the effects seen were, in fact, real.

    This is important as I had described prior to this week to find out if I was simply another victim of placebo/nocebo effects - which apparently the answer is NO. [But we are only at the half-way point of our trials, there are still many questions to be answered...

    A couple other notes are the potential confounding variables:
    A good researcher ALWAYS lets you in on potential flaws to the study and confounding variables are the biggest things to look for.
    (1) Sampling Bias...this wasn't 100% random - I had already known I was going to have 3 days of each - so exact chance wasn't a true possibility due to limitations.
    (2) Population Bias...would my results be applicable to the entire population? This plays out in a couple of ways. For the aforementioned week, it is worth noting that I was defining myself as on an empty stomach, having eaten 2 hours prior to ingestion of placebo or YN. To get similar results, the trial would have to be repeated in the virtually exact manner. Now, this also includes which days I lifted with the YN and which days I lifted with the placebo (i.e. - would the same effects have been seen if I lifted for arms with YN vs. the placebo the way it was done in this trial, does time of day impact the trial at all - some days I was working out at 6:00am, others - 8:00am...how does this affect it). Don't think I stop here...I am certainly going to attempt to gain answers to these in the next couple of weeks and eliminate rationale for people to be concerned about confounding variables. As I have suggested throughout my trial - MORE STUDY IS NEEDED...right now, I can say that the "effects" are certainly different vs. placebo. I CAN differentiate which ones I get (YN or Placebo; Thursday again was tricky, but I have pointed out other factors that could have contributed there) secondary to effects seen/felt. I cannot underscore enough how important that is for a scientific skeptic!


    I told you Yellow nEuphoria would be the MOST HIGHLY SCRUTINIZED PRODUCT in a user's review EVER (hands down here)...so we still have blood work, we still have EMG (thus far - effects have been slim to none on blood pressure, but we will still hone in more answers to vital signs effects later in the trial).


    Until next time...

    PREVIEW

    (1) Independent Supplement Review Part IV
    (2) Blood Work Results


    Thanks for watching...

    D_

  4. #44
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    Default

    Very cool log. I am a pharmaceutical guy, so it is really neet to see someone apply solid scientific measures such as pharmacokinetic analysis and statistical significance. Although, I do agree that the power (n) of your study may be inadequate in numbers. Anyways, good stuff! One request. Can you change the small yellow print font to a different color? It is really hard to read. Take care!

  5. #45
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    Default

    Quote Originally Posted by dinoiii
    First, the unveiling of what was contained in each envelope:

    Monday: Yellow nEuphoria
    Tuesday: Placebo
    Wednesday: Day Off
    Thursday: Yellow nEuphoria
    Friday: Placebo
    Saturday: Placebo
    Sunday: Yellow nEuphoria

    The good news is that the effect was rather predictable on most occasion - Thursday being the most challenging to differentiate as the effect was subtle if you recall from the day-to-day accounts. Some confounding factors that likely contributed to this were the fact that I was really concentrating on not having a repeat terrible leg day as I did in week 1 (recall my "deer in the headlight" effect while on the hack squat machine - verified by bystanders).



    For our comparative analysis of my experience on a star basis of the Yellow nEuphoria vs. Placebo based on claims in the Controlled labs ad campaign look as follows in a table I constructed accounting for averages of the 3 days of each item:



    Now, I will cut and paste the rating scale I have used alongside this trial for your ease:

    Dinoiii's Rating Scale KEY:
    * Insignificant Effect
    ** Slight Effect, Still Insignificant
    *** Average Effect
    **** Statistically Significant Effect
    ***** Dinoiii's Praise (statistical significance doesn't describe this!)


    And for your corneal pleasure....look into the yellow mess below prior to even thinking about asking me to assign statistical significance to these values seen in the table.



    It cannot be done effectively without me "fudging" the numbers due to a small "N" - namely n=1 in this trial, too small a POWER effect to assign significance, however - it does affirm that the effects seen were, in fact, real.

    This is important as I had described prior to this week to find out if I was simply another victim of placebo/nocebo effects - which apparently the answer is NO. [But we are only at the half-way point of our trials, there are still many questions to be answered...

    A couple other notes are the potential confounding variables:
    A good researcher ALWAYS lets you in on potential flaws to the study and confounding variables are the biggest things to look for.
    (1) Sampling Bias...this wasn't 100% random - I had already known I was going to have 3 days of each - so exact chance wasn't a true possibility due to limitations.
    (2) Population Bias...would my results be applicable to the entire population? This plays out in a couple of ways. For the aforementioned week, it is worth noting that I was defining myself as on an empty stomach, having eaten 2 hours prior to ingestion of placebo or YN. To get similar results, the trial would have to be repeated in the virtually exact manner. Now, this also includes which days I lifted with the YN and which days I lifted with the placebo (i.e. - would the same effects have been seen if I lifted for arms with YN vs. the placebo the way it was done in this trial, does time of day impact the trial at all - some days I was working out at 6:00am, others - 8:00am...how does this affect it). Don't think I stop here...I am certainly going to attempt to gain answers to these in the next couple of weeks and eliminate rationale for people to be concerned about confounding variables. As I have suggested throughout my trial - MORE STUDY IS NEEDED...right now, I can say that the "effects" are certainly different vs. placebo. I CAN differentiate which ones I get (YN or Placebo; Thursday again was tricky, but I have pointed out other factors that could have contributed there) secondary to effects seen/felt. I cannot underscore enough how important that is for a scientific skeptic!


    I told you Yellow nEuphoria would be the MOST HIGHLY SCRUTINIZED PRODUCT in a user's review EVER (hands down here)...so we still have blood work, we still have EMG (thus far - effects have been slim to none on blood pressure, but we will still hone in more answers to vital signs effects later in the trial).


    Until next time...

    PREVIEW

    (1) Independent Supplement Review Part IV
    (2) Blood Work Results


    Thanks for watching...

    D_
    Nice !!

  6. #46
    Join Date
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    Default

    I have been meaning to do this for such a long time, but I have about 4,000 commitments (as pt knows - likely tank does too).

    For those that did struggle with the visuals, you can visit it as it was intentioned on a black background over at discountanabolics.com.

    I will provide the link for ease:
    http://www.discountanabolics.com/for...ead.php?t=5822

    I hope you stop by...it went on and on, but I was so unable to keep up. I have accepted multiple new appointments, so it is just very intense for me right now. I appreciate all comments that have been made - and the most recent by AJM would apply most. You may find the look over there a lot easier on the eyes.


    And thanks pt. I try, but despite my lengthy posts, I am just unable to surmass such post tallies in multiple spots likely someone I know.




    D_

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